Trialchemy
Open beta · 21 designs · 7 families

Open clinical trial design

Trialchemy is the workbench for designing, simulating, and comparing trials across all phases.

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21 designs across 7 families

Family·6 designs

Phase I dose finding

MTD search, algorithmic and model-based.

3+3BOINmTPI-2CRMTITE-CRMBLRM
Family·3 designs

Phase III two-arm

Confirmatory sample size for three endpoint families.

BinaryContinuousSurvival
Family·3 designs

Treatment selection

Multi-arm and adaptive selection.

Sargent-GoldbergMulti-arm GSAdaptive
Family·3 designs

Non-inferiority

NI margin sample size, three endpoints.

BinaryContinuousSurvival
Family·2 designs

Phase II single arm

Two-stage and single-stage screening.

Simon'sA'Hern
Family·2 designs

Phase II dose response

MCP-Mod and Emax non-linear fit.

MCP-ModEmax
Family·2 designs

Dose optimization

Project Optimus, OBD with toxicity and efficacy.

BOIN-ETKeyboard OBD
Open methodology

Every design is a thin adapter over published R packages: rpact, OncoBayes2, DoseFinding, BOIN, Keyboard, dfcrm, clinfun. No black box.

Cross-design comparisons

Compare different designs under the same scientific objective. Within-design scenario stacking is included; the cross-design view is what makes Trialchemy more than a calculator.

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